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Leptin signaling and leptin resistance

Yingjiang Zhou, Liangyou Rui

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 207-222 doi: 10.1007/s11684-013-0263-5

Abstract:

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energyLeptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesityLeptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neuronsLeptin resistance is the key risk factor for obesity.This review is focused on recent advance about leptin action, leptin signaling, and leptin resistance

Keywords： leptin signaling     leptin receptor     energy balance     leptin resistance     obesity    

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Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: Leptin resistance is a main mechanism of acquired childhood obesity, and the suppression of long formof leptin receptor (OBRb) gene expression in diet-induced obese rats indicates that the down-regulationof OBRb gene expression plays a pivotal role in the mechanism of leptin resistance.

Keywords： receptors     leptin     RNA interference     lentivirus vector    

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Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3,   Pages 222-230 doi: 10.15302/J-FASE-2016106

Abstract: AMPK is the energy status sensor, the core nutrient signaling component and the metabolic kinase of cellsThis review mainly focuses on the mechanism of autophagy regulated by nutrient signaling especially for

Keywords： Autophagy     ULK1 complex     VPS34 complex     AMPK     mTOR     nutrient signaling    

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The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 352-355 doi: 10.1007/s11684-007-0067-6

Abstract: The aim of this paper was to investigate the change of serum leptin and its relationship with plateletSerum leptin was detected by enzyme linked immunosorbent assay.Multifactorial stepwise regression analysis showed that serum leptin in CHD patients was independentlyLogistic analysis demonstrated that serum leptin was independently correlated with the risk of CHD (leptin could affect blood platelet activation.
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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: pathways, including Wnt and Notch signaling.The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleBoth signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochleaIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: the levels of calcium ions (Ca2+) and the expression of key genes involved in the calcium signaling

Keywords： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 1-7 doi: 10.1007/s11684-009-0018-5

Abstract: Physiologically, ROS are involved in many signaling cascades that contribute to normal processes.As signaling messengers, ROS are able to oxidize many targets such as DNA, proteins and lipids, whichThe present review summarizes recent advances in our comprehensive understanding of ROS-linked signaling

Keywords： free radicals     tumor     phox     cell proliferation     cancer therapy    

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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 87-92 doi: 10.1007/s11684-007-0017-3

Abstract: The aim of this paper is to explore the effect of intestinal ischemia/reperfusion (I/R) injury on leptinand orexin-A levels in peripheral blood and central secretory tissues, and to examine the roles of leptinRadioimmunoassay was employed to detect the levels of leptin in serum and adipose tissue and orexin-A, adipose leptin levels of I60´R30´ and I60´R90´ decreased, and adipose leptin in I60´R360´ group increasedLeptin and orexin-A respond to intestinal I/R injury in a time-dependent manner, with leptin responding

Keywords： significant difference     intestinal I/R     transcriptase-polymerase     metabolic     central secretory    

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Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 431-436 doi: 10.1007/s11684-015-0416-9

Abstract: The Slit/Robo signaling pathway is reportedly involved in breast cancer development and metastasis.induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signalingFurthermore, loss of Slit proteins or their Robo receptors upregulates the CXCL12/CXCR4 signaling axisThis review includes recent studies on the functions of Slit/Robo signaling in breast cancer and its

Keywords： Slit/Robo     hypermethylation     β-catenin     CXCL12/CXCR4     migration    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: -catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and disease-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract: This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs

Keywords： planar cell polarity     neural tube defects     rare mutations    

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 316-332 doi: 10.15302/J-FASE-2022441

Abstract:

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

Keywords： Nitrogen     root system architecture     phytohormone     crosstalk     nitrogen-use efficiency     breeding strategy    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: mutations, leading to abnormal expression of downstream target genes and aberrant activation of various signalingIn particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by somereceptor (or cPRL receptor), indicating that SOCS1a and SOCS1b proteins can negatively regulate GH/PRL signaling

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Title Author Date Type Operation

Leptin signaling and leptin resistance

Yingjiang Zhou, Liangyou Rui

Journal Article

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Journal Article

Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Journal Article

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Journal Article

Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Journal Article

Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article

ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article